Hope Beyond the Flare-Up: A New Clinical Trial for Chronic Pouchitis
OPUS-Pouch Study
If chronic pouchitis is disrupting life after ileal pouch-anal anastomosis (IPAA), also known as J-pouch surgery, a new investigational product—CLF065—may offer a path forward. The OPUS-Pouch Study is now enrolling participants who haven’t found lasting relief with current treatments.
A Potential New Option When Nothing Else Has Worked
This pouchitis clinical trial is part of a Phase 2 research study evaluating the safety and effectiveness of CLF065, a long-acting, once-weekly injection. This randomized, placebo-controlled clinical trial is exploring whether CLF065 can reduce inflammation and improve symptoms in people living with chronic pouchitis after J-pouch surgery.
What Is Pouchitis?
Pouchitis is the most common complication after J-pouch surgery and can lead to symptoms like urgency, diarrhea, and fatigue. When these symptoms keep returning, it’s called chronic pouchitis.
Have Questions?
Take the Next Step
Whether you’re considering this clinical trial for yourself or a loved one, we’re here to help. Contact our team and learn more about participating in the OPUS-Pouch Study.
At-a-Glance: Who May Qualify
- Ages 18 to 80
- Had J-pouch surgery at least 1 year ago
- Have had 3+ pouchitis episodes in the last year or use long-term antibiotics
- Willing to pause antibiotics and taper steroids
- Able to attend regular clinic visits